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. 2018 Mar 14;9:457. doi: 10.3389/fimmu.2018.00457

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Copyright © 2018 Hossain, Morandi, Tanasescu, Frakich, Caldano, Onion, Faraj, Erridge and Gran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR2 surface expression in relapsing-remitting MS patients and effect of Calpain on TLR2 expression. (A,B) Representative flow cytometry dot plots showing percentage of CD4+ TLR2+ cells for the same patient during relapse and remission. Cells were gated on lymphocytes then live cells and then double gated for CD4 and TLR2. (C) Graphs showing the percentage of CD4+ TLR2+ lymphocytes comparing between relapse and remission in paired samples (n = 14). Data are presented as mean ± SD. Wilcoxon matched-pairs signed rank test gave the P value of 0.1937 showing no significant difference in TLR2 surface expression between relapse and remission.