A left transition zone lesion (arrow) on (A) axial T2-weighted image, (B) high-b-value DWI, (C) early DCE time-point, and (D) ADC map. The overall PI-RADS assessment category 3 was assigned (T2w 3, DWI/ADC 4, DCE +). On subsequent targeted MRI/US fusion biopsy, the lesion exhibited Gleason score 3+4 tumor (red arrows). PI-RADS category 3 lesions in the transition zone are characterized as heterogeneous signal intensity with obscured margins, together with focal mildly to moderately hypointense on ADC, and isointense to mildly hyperintense on high b-value DWI. Focal enhancement on DCE MRI may be present. The dominant sequence in PI-RADS v2 is T2w. (E-H) A left transition zone lesion (blue arrows). The overall PI-RADS assessment category 3 was assigned (T2w 3, DWI/ADC 4, DCE −). On subsequent targeted MRI/US fusion biopsy, the lesion exhibited no prostate cancer (blue arrows).