Table 4. Subgroup analysis of rs1800629 and rs361525 in TNF-α.
| Polymorphism | Genetic model | Ethnicity | Number of datasets | OR (95% CI) | P-value | Test of heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 | P-value | ||||||
| rs1800629 | AA compared with GG | Asian | 6 | 1.40 [0.64, 3.06] | 0.396 | 27.3% | 0.230 |
| European | 3 | 2.31 [1.35, 3.95] | 0.002 | 0.0% | 0.713 | ||
| GA compared with GG | Asian | 6 | 0.91 [0.50, 1.69] | 0.772 | 79.9% | 0.000 | |
| European | 3 | 2.14 [1.55, 2.95] | 0.000 | 53.8% | 0.115 | ||
| AA + GA compared with GG | Asian | 6 | 0.90 [0.50, 1.61] | 0.720 | 79.3% | 0.000 | |
| European | 3 | 2.18 [1.67, 2.84] | 0.000 | 38.0% | 0.199 | ||
| AA compared with GA + GG | Asian | 6 | 1.32 [0.60, 2.87] | 0.489 | 25.3% | 0.245 | |
| European | 3 | 1.78 [1.04, 3.02] | 0.000 | 0.0% | 0.605 | ||
| A compared with G | Asian | 6 | 0.89 [0.53, 1.48] | 0.647 | 77.7% | 0.000 | |
| European | 3 | 1.9 [1.60, 2.28] | 0.000 | 0.0% | 0.46 | ||
| rs361525 | AA compared with GG | Asian | 4 | 3.61 [0.75, 17.3] | 0.109 | 72.8% | 0.055 |
| European | 2 | 1.09 [0.33, 3.55] | 0.891 | 0.0% | 0.429 | ||
| GA compared with GG | Asian | 4 | 2.02 [0.32, 12.69] | 0.452 | 96.1% | 0.000 | |
| European | 2 | 0.80 [0.20, 3.16] | 0.746 | 90.0% | 0.002 | ||
| AA + GA compared with GG | Asian | 4 | 2.04 [0.32, 13.07] | 0.453 | 96.2% | 0.000 | |
| European | 2 | 0.78 [0.19, 3.20] | 0.725 | 90.7% | 0.001 | ||
| AA compared with GA + GG | Asian | 4 | 2.82 [0.53, 15.1] | 0.225 | 53.4% | 0.143 | |
| European | 2 | 1.04 [0.32, 3.41] | 0.946 | 0.0% | 0.470 | ||
| A compared with G | Asian | 4 | 1.85 [0.35, 9.87] | 0.469 | 95.8% | 0.000 | |
| European | 2 | 0.76 [0.19, 3.05] | 0.694 | 90.8% | 0.001 | ||
P < 0.05 was considered statistically significant.