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. 2018 Feb 1;7(2):bio029637. doi: 10.1242/bio.029637

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Loss of HDAC1 causes wing notching in Drosophila. (A-C) Adult wings from flies expressing the following transgenes under the control of en-Gal4: (A) control, (B) UAS-HDAC1 RNAi, (C) UAS-HDAC1 RNAi and UAS-HDAC1. Depletion of HDAC1 causes loss of wing margin tissue. The posterior half of the wing is marked by grey shadow. (D) Quantification of wing size of flies with the indicated genotypes. The ratio was defined by the posterior wing area divided by total wing area. n=5 for each genotype. **P<0.01. (E,F) Adult wings from flies bearing HDAC1^[303] (E) or HDAC1^[def24] (F) MARCM mutant clones exhibit wing notches. (G-I) Adult wings from flies with the indicated genotypes. Wings from N^[1]/+; HDAC1^[303]/+ doubly heterozygotes display notched wing margin with higher frequency compared to N^[1]/+ heterozygotes. (J) Quantification of Notch wing phenotype in N^[1]/+ (n=62), HDAC1^[303]/+(n=75) and N^[1]/+; HDAC1^[303]/+ (n=122) flies.