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. 2018 Feb 1;7(2):bio029637. doi: 10.1242/bio.029637

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — HDAC1 acts upstream of Notch activation. (A-D″) Co-expression of HDAC1 RNAi with the active form of Notch (NICD) does not suppress NICD-induced ectopic Cut expression. Wing discs from animals expressing the following transgenes with the Flip-out system: (A) control, (B) UAS-HDAC1 RNAi, (C) UAS-NICD, (D) UAS-NICD and UAS-HDAC1 RNAi, stained with anti-Cut and anti-GFP. DNA was stained with DAPI. Clones are marked by dashed lines. (E-H″) Co-expression of HDAC1 RNAi with the active form of Notch (NICD) does not suppress NICD-induced ectopic Wingless expression. Wing discs from animals expressing the following transgenes with the Flip-out system: (A) control, (B) UAS-HDAC1 RNAi, (C) UAS-NICD, (D) UAS-NICD and UAS-HDAC1 RNAi, stained with anti-Wingless and anti-GFP. DNA was stained with DAPI. Clones are marked by dashed lines. Arrows indicate cells with non-autonomous Wingless expression. Scale bars: 50 μm.