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. 2018 Feb 15;7(2):bio030494. doi: 10.1242/bio.030494

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Zebrafish Claudin 5a is the homologue of human claudin 5. (A) Protein sequence alignment of human (Hs; Homo sapiens) claudin 5, zebrafish (Dr; Danio rerio) Claudin 5a and Claudin 5b using Clustal Omega. (B,C) Syntenic analysis of claudin 5a (B) and claudin 5b (C) genes. (B) Green: Syntenic genes in the claudin 5a locus across Latimeria chalumnae (Lc), Oryzias latipes (Ol), Danio rerio (Dr), Xenopus laevis (Xl) and Homo sapiens (Hs). Purple: Syntenic genes in the claudin 5a locus across Osteichthyes (Lc, Ol, Dr). Blue: Unique gene present in the claudin 5a locus of Xenopus laevis. Open bar, 250 Kb. (C) Claudin 5b is only present in Actinopterygii (ray-finned fish), here represented by Oryzias latipes (Ol) and Danio rerio (Dr), which show conserved synteny. Syntenic genes in the claudin 5b locus across Actinopterygii.