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. 2018 Feb 15;7(2):bio030494. doi: 10.1242/bio.030494

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Developmental expression of claudin 5a. (A) Lateral view of a Casper zebrafish larva at 1 dpf and 7 dpf. Boxed areas represent the brain regions of which confocal images are shown in B-J. (B-J) Z-stacks of dorsal view of larval head to visualize development of GFP expression from 1 to 9 dpf. GFP expression can be found in the dCP and mCP from 1 dpf onwards (B, closed arrow). In addition, labelling is observed in the midline connecting the dCP and mCP (B, open arrow, J’). From 3 dpf onwards, labelling in brain parenchyma is observed (D, open arrow). (K) Diffuse GFP expression in brain region of adult zebrafish, 1.5 years, with corresponding brightfield image. The boxed area in K and its inset is enlarged in M and L, respectively. (L) Brightfield image of blood vessel in adult brain, colocalizing with (M) Claudin 5a:GFP expression. Scale bars: 100 μm in B-J; 1 mm in K; 200 μm in L,M.