Figure 4.

The ‘cis& trans’ spreading model with epigenomic-driven self-attraction (ϵ_c = ϵ_t ≡ ϵ, ϵ_o = 0.001, k_u = 0.001). Epigenomic phase diagram in the (ϵ/ϵ_o, k_b/k_u) plane. The monostable and multimodal/bistable regions are demarcated by the transition black curve. Due to finite-size effects, the observed multimodality might not reflect a true bistable dynamics (see text). The limit between multimodality and bistability is represented by the black dashed line. (A_{1, .., 6}). Examples of time evolution of the local epigenomic state, of the global epigenomic state and of the radius of gyration R_g for ϵ/ϵ_o = 1, k_b/k_u = 0 (A₁), ϵ/ϵ_o = 1, k_b/k_u = 0.15 (A₂), ϵ/ϵ_o = 1, k_b/k_u = 0.2 (A₃), ϵ/ϵ_o = 3, k_b/k_u = 0 (A₄), ϵ/ϵ_o = 3, k_b/k_u = 0.15 (A₅) and ϵ/ϵ_o = 3, k_b/k_u = 0.2 (A₆).