Figure 5.

(A) Stability of the global epigenomic state for the ‘cis &trans’ spreading model with epigenomic-driven self-attraction (ϵ_c = ϵ_t ≡ ϵ, ϵ_o = 0.001, k_u = 0.001). Heatmap of the MFPT 〈τ〉 to switch from the I macro-state s = −1 to a A state (s > 0) (see ‘Materials and Methods’ section) as a function of the attraction k_b/k_u and recruitment strength ϵ/ϵ_o. The monostable and multimodal/bistable regions are demarcated by the transition black curve. (B and C) Epigenomic phase diagrams for different dynamical regimes (B) Transition curves for an epigenomic dynamics ten times slower (ϵ_o = 0.0001) (gray) and ten times faster (ϵ_o = 0.01) (red) than the reference case considered in Figure 4A) (ϵ_c = ϵ_t, ϵ_o = 0.001) (black). (C) Transition curve for a cis spreading ten times greater than the trans spreading (ϵ_c = 10ϵ_t, ϵ_o = 0.001) (red) and for the reference case (ϵ_c = ϵ_t, ϵ_o = 0.001) (black). In (A–C) the limit between multimodality and bistability is represented by the black dashed line.