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. 2018 Feb 7;46(5):2169–2184. doi: 10.1093/nar/gky095

Figure 1.

Figure 1.

Long noncoding RNAs regulate the phosphorylation status of splicing factors. (i) NEAT1 (blue) modulates SRp40 phosphorylation status by interaction with the Clk kinase. Phosphorylated SRp40 promotes the processing of the PPARy pre-mRNA into the PPARy2 mRNA, whereas the dephosphorylation of SRp40 favors the accumulation of the PPARy1 isoform. ( ii) MALAT1 (red) was proposed to modulate the phosphorylation status of SR proteins in the nucleus, including the MALAT1-interacting SRSF1, likely by interaction with PP1/2A phosphatases or with the SRPK1 kinase. Phosphorylated SRSF1 is accumulated in nuclear speckles (NS), whereas its dephosphorylation promotes the interaction with mRNAs (green), their transport and accumulation in the cytoplasm, likely affecting also protein translation and/or incorporation into P-bodies (PB) hosting the non-sense mediated decay (NMD) machinery. The three question marks indicate that each step was proposed albeit non validated.