Table 4.
Demographics, Clinical Features, Site of Infection, and Outcomes for 296 Patients With MSSA Bacteremia Treated With Either Vancomycin or a Beta-Lactam
| Characteristics | Definitive Antibiotic Choice | P | |
|---|---|---|---|
| Vancomycin (n = 53), No. (%) |
Beta-lactam (n = 243), No. (%) |
||
| Demographics | |||
| Age, mean (SD), y | 55.5 (17) | 58.0 (16) | .35 |
| Male | 31 (58) | 161 (66) | .34 |
| SOFA, mean (SD) | 3.7 (3.1) | 2.9 (2.5) | .04 |
| CCmI, mean (SD) | 6.6 (3) | 5.5 (3) | .03 |
| Penicillin allergic | 25 (47) | 32 (13) | <.01 |
| Site of infection | |||
| Catheter | 9 (17) | 35 (14) | .67 |
| Pneumonia | 6 (11) | 15 (6) | .23 |
| Endovascular | 12 (23) | 53 (22) | .86 |
| Osteoarticular | 4 (8) | 49 (20) | .03 |
| Soft tissue | 11 (21) | 55 (23) | .86 |
| Unknown | 14 (26) | 53 (22) | .47 |
| Treatment | |||
| Vancomycin trough, mean (SD) | 18.0 (6.1) | 15.3 (6.6) | .10 |
| Duration, mean (SD), wk | 4.3 (1.8) | 4.5 (1.8) | .57 |
| ID consultation | 28 (53) | 159 (65) | .12 |
| Outcomes | |||
| Time to clearance, mean (SD), d | 5.0 (5.3) | 4.4 (4.2) | .47 |
| 30-d mortality (%) | 12 (22.6) | 18 (7.4) | <.01 |
| 90-d mortality (%) | 14 (26.4) | 33 (13.6) | .04 |
| 90-d recurrence (%) | 5 (9.4) | 3 (1.2) | <.01 |
Abbreviation: CCmI, Charlson co-morbidity index; MSSA, methicillin-susceptible Staphylococcus aureus; SOFA, sequential organ failure assessment.