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OTI28 inhibits DNA ligation and stabilizes cleavage complexes similarly to free etoposide. (A) Enzyme-mediated ligation of DNA. (B) Persistence of cleavage complexes. For both A and B, cleavage results of the unmodified PML duplex in the presence of 500 μM free etoposide are shown in blue and those with an unmodified PML top/target strand hybridized to OTI28 are shown in yellow. Error bars represent the standard deviation of at least three independent experiments.
