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. 2018 Feb 13;46(5):2218–2233. doi: 10.1093/nar/gky072

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — An oligonucleotide with an abasic site analog at position 28 generates a different DNA cleavage pattern than does OTI28. Lanes 1–3 contain a radiolabeled unmodified PML top/target strand hybridized to an unmodified PML bottom strand in the absence of enzyme, or in the presence of enzyme and 0–500 μM free etoposide. Lanes 4 and 5 contain a radiolabeled PML top strand hybridized with OTI28 (bottom strand). Lanes 6 and 7 contain a radiolabeled unmodified PML top strand hybridized to a bottom strand oligonucleotide containing an abasic site analog at position 28 (AP28). Lane 8 contains reference (R) oligonucleotides that are 24, 23 and 19 bases in length. The gel is representative of at least three independent experiments.