Fig. 4.

Regeneration strategy of proteins specific to the heart, cerebellum, fin, and retina in the recalled-blastema-like regenerative model. In heart-specific proteins, Integrin, PDGF, and FGF co-regulate binding affinity of fibrin and fibrinogen for platelets to speed hemostasis in the injury response step. In cerebellum-specific pathways, Wnt signaling promotes formation of the recalled-blastema-like formation via Wnt3 and participates in the regulation of neuronal differentiation and cerebellum structure via Wnt3a and Ppp2ca. For fin-specific proteins, it was observed that angiogenesis provides nutrition to promote the recalled-blastema-like formation and pattern formation through Wnt signaling. In retina-specific proteins, Bdnf enhances optic cell survivability and stabilizes the regeneration process. These proteins may trigger differentiation and de-differentiation processes for the zebrafish regeneration process