Table 3.

CKD outcomes in the CKD and non-CKD subgroups, stratified by treatment group and race/ethnicity

Outcome	Subgroup	Intensive arm			Standard arm			Intensive vs. standard hazard ratio			Interaction P value
		N	Events	% per Year	N	Events	% per Year	HR	Lower 95% CI	Upper 95% CI
CKD subgroup: composite renal outcomea	(Non-Hispanic) White	885	8	0.3	893	7	0.24	1.14	0.38	3.41	0.76
	(Non-Hispanic) Black	325	9	0.9	312	8	0.79	1.09	0.40	3.14
	Hispanic	94	0	0.0	96	0	0.00	–	–	–
CKD subgroup: incident albuminuriab	(Non-Hispanic) White	365	49	4.3	346	60	5.7	0.79	0.53	1.18	0.17
	(Non-Hispanic) Black	118	11	3.0	106	18	5.7	0.26	0.08	0.69
	Hispanic	35	4	3.7	41	7	5.8	1.39	0.28	7.17
Non-CKD subgroup: ≥30% eGFR reduction to CKDc	(Non-Hispanic) White	1,808	88	1.5	1,798	21	0.4	4.38	2.77	7.24	0.22
	(Non-Hispanic) Black	1,046	42	1.3	1,103	16	0.5	2.61	1.47	4.83
	Hispanic	406	17	1.3	383	4	0.3	4.02	1.44	14.3
Non-CKD subgroup: incident albuminuria	(Non-Hispanic) White	965	81	2.7	955	101	3.4	0.77	0.57	1.03	0.51
	(Non-Hispanic) Black	576	45	2.5	642	65	3.4	0.73	0.49	1.08
	Hispanic	219	15	2.1	213	15	2.2	0.80	0.36	1.75

Abbreviations: CI, confidence interval, CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate.

^aFor participants with CKD at baseline, composite renal outcome was the first occurrence of a reduction in eGFR by 50% (measure twice at least 90 days apart) or long-term dialysis or kidney transplant.

^bIncident albuminuria denotes a urinary albumin to creatinine ratio of less than 10 mg/g at baseline and doubled to a creatinine ratio from less than 10 mg/g to 10 mg/g or greater (measured twice at least 90 days apart).

^cIncludes a 30% reduction in eGFR (measured twice at least 90 days apart) to an eGFR of less than 60 ml/min/1.73 m², dialysis, or a kidney transplant in participants without CKD at baseline.