Table 1.
Baseline characteristics by Cornell voltage left ventricular hypertrophy at baseline for subjects with baseline electrocardiogram
| Total | Cornell voltage LVH No | Cornell voltage LVH Yes | P | |
|---|---|---|---|---|
| N a | 26,384 | 24,643 | 1,741 | |
| Age—mean (SD) years | 66.7 (7.6) | 66.6 (7.5) | 67.4 (8.4) | <0.001 |
| Female—n (%) | 12,207 (46.3) | 10,920 (44.3) | 1,287 (73.9) | <0.001 |
| Black—n (%) | 9,020 (34.2) | 8,020 (32.5) | 1,000 (57.4) | <0.001 |
| Hispanic—n (%) | 4,515 (17.1) | 4,218 (17.1) | 297 (17.1) | 0.951 |
| Systolic blood pressure—mean (SD) mm Hg | 146 (16) | 146 (16) | 151 (15) | <0.001 |
| Diastolic blood pressure—mean (SD) mm Hg | 84 (10) | 84 (10) | 86 (11) | <0.001 |
| Heart rate—mean (SD) beats/min | 73 (11) | 73 (11) | 74 (11) | <0.001 |
| Body mass index | 29.7 (6.1) | 29.7 (6.1) | 29.9 (6.3) | 0.232 |
| Current smoker—n (%) | 5,868 (22.2) | 5,534 (22.5) | 334 (19.2) | 0.002 |
| Atherosclerotic coronary vascular disease—n (%) | 13,483 (51.1) | 12,617 (51.2) | 866 (49.7) | 0.240 |
| Type II diabetes—n (%) | 9,257 (35.1) | 8,627 (35.0) | 630 (36.2) | 0.319 |
| History of coronary heart disease—n (%) | 6,571 (25.1) | 6,198 (25.4) | 373 (21.6) | 0.001 |
| Aspirin use—n (%) | 9,623 (36.5) | 9,122 (37.0) | 501 (28.8) | <0.001 |
| Assigned antihypertensive treatment group | 0.750 | |||
| Chlorthalidone—n (%) | 12,106 (45.9) | 11,322 (45.9) | 784 (45.0) | |
| Amlodipine—n (%) | 7,152 (27.1) | 6,670 (27.1) | 482 (27.7) | |
| Lisinopril—n (%) | 7,126 (27.0) | 6,651 (27.0) | 475 (27.3) | |
| Potassium—mean (SD) mEq/l | 4.3 (0.5) | 4.3 (0.5) | 4.2 (0.5) | <0.001 |
| Glucose—mean (SD) mg/dl | 123.5 (59.6) | 123.3 (59.3) | 126.4 (63.6) | 0.041 |
| Estimated glomerular filtration rate—mean (SD) ml/min per 1.73 m2†,b | 77.8 (19.4) | 77.9 (19.3) | 76.2 (21.5) | 0.001 |
| Cholesterol—mean (SD) mg/dl | 216.3 (43.2) | 215.7 (43.0) | 223.7 (45.9) | <0.001 |
| LDL—mean (SD) mg/dl | 136.0 (36.9) | 135.6 (36.8) | 141.2 (38.6) | <0.001 |
| HDL—mean (SD) mg/dl | 46.8 (14.8) | 46.5 (14.7) | 50.8 (16.0) | <0.001 |
| Triglycerides mean (SD) mg/dl | 176.8 (136.6) | 177.6 (135.1) | 165.4 (155.6) | <0.001 |
Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein; LVH, left ventricular hypertrophy.
aYears to death, mean (SD): Total = 5.0 (1.4); Cornell voltage LVH No = 5.0 (1.3), Yes = 4.9 (1.5); P < 0.001.
bSimplified 4-variable Modification of Diet in Renal Disease Study Formula.