Figure 5.

Effect of high fat diet on mRNA expression of proinflammatory markers and antioxidant defense in the kidney and heart of transgenic mice by quantitative RT-PCR analysis: functional relevance of the upregulated hAT1R was assessed by relative mRNA expression analysis of the proinflammatory, pro-oxidative genes including IL6, CRP, TNFα, NOX1 (a, kidney; c, heart), and antioxidant defense markers SOD1 and HO1 (b, kidney; d, heart) after HFD treatment. *P < 0.05 compared with Hap II after HFD. Results are shown as mean ± SE (n = 4). Abbreviations: CRP, C-reactive protein; HFD, high fat diet; RT-PCR, real-time polymerase chain reaction; TNFα, tumor necrosis factor alpha.