Table 1.
Tagging SNP rs2540923 analysis for new cohort
| Major allele homozygotes (GG), (n = 290) | Minor allele carriers (AG + AA), (n = 41) | P value | |
|---|---|---|---|
| Sex | |||
| Females (%) | 143 (49.3) | 23 (56.1) | |
| Males (%) | 147 (50.7) | 18 (43.9) | 0.42 |
| Race (%) | |||
| Caucasians | 204 (77.9) | 8 (19.5) | |
| Blacks | 58 (22.1) | 33 (80.5) | <0.0001 |
| Disease status (%) | |||
| Hypertensive with diabetes mellitus | 26 (9.3) | 5 (12.5) | |
| Hypertensive | 80 (28.4) | 15 (37.5) | |
| Normotensive | 175 (62.3) | 20 (50.0) | 0.14 |
| Age, years | 43.2 ± 11.6 | 41.9 ± 10.2 | 0.49 |
| BMI, kg/m2 | 26.5 ± 4.4 | 28.7 ± 4.8 | 0.003 |
| SBP on liberal salt, mm Hg | 123.3 ± 22.4 | 137.4 ± 27.4 | 0.001 |
| Mean aldosterone, ng/dl | 4.4 ± 3.4 | 4.4 ± 3.7 | 0.98 |
| Upright PRA, ng/(ml * hour) | 8.4 ± 6.3 | 6.6 ± 5.0 | 0.08 |
Data for continuous variables represent means ± SD. Abbreviations: BMI, body mass index; PRA, plasma renin activity; SBP, systolic blood pressure; SNP, single-nucleotide polymorphism.