Table 3.
Tagging SNP rs2540923 analysis for combined study population
| Major allele homozygotes (GG), (n = 637) | Minor allele carriers (AG + AA), (n = 59) | P value | |
|---|---|---|---|
| Sex | |||
| Females (%) | 284 (44.6) | 32 (54.2) | |
| Males (%) | 353 (55.4) | 27 (45.8) | 0.15 |
| Race (%) | |||
| Caucasians | 551 (90.5) | 26 (44.1) | |
| Blacks | 58 (9.5) | 33 (55.9) | <0.0001 |
| Disease status (%) | |||
| Hypertensive with diabetes mellitus | 26 (4.1) | 5 (8.6) | |
| Hypertensive | 427 (68.0) | 33 (56.8) | |
| Normotensive | 175 (27.9) | 20 (34.6) | 0.29 |
| Age, years | 45.9 ± 10.5 | 45.3 ± 10.6 | 0.66 |
| BMI, kg/m2 | 27.3 ± 4.2 | 28.9 ± 4.7 | 0.005 |
| SBP on liberal salt, mm Hg | 137.0 ± 23.4 | 142.2 ± 25.6 | 0.12 |
| Mean aldosterone, ng/dl | 5.1 ± 3.8 | 4.7 ± 3.8 | 0.55 |
| Upright PRA, ng/(ml * hour) | 7.8 ± 6.5 | 6.3 ± 4.9 | 0.11 |
Data for continuous variables represent means ± SD. Abbreviations: BMI, body mass index; PRA, plasma renin activity; SBP, systolic blood pressure; SNP, single-nucleotide polymorphism.