Figure 3.

Increased MIF expression in the NTS restores baroreflex function in 2K1C rats. Baroreflex function was analyzed in normotensive (NT) or 2K1C rats that received intra-NTS injections of AAV2-CBA-eGFP or AAV2-CBA-MIF vectors. (a) Grouped heart rate (HR) baroreflex slope in response to each 10 mm Hg change in mean arterial pressure (MAP) elicited by phenylephrine (pressor) or sodium nitroprusside (depressor); (b) Spontaneous baroreflex analysis, as follows; UP gain, DOWN gain, and Total gain. Data are presented as mean ± SEM; n = number of rats. In panel b the numbers of rats/group are inside the bars; *P < 0.05 vs. NT groups, ^#P < 0.05 vs. 2K1C-GFP; 1-way ANOVA, followed by Student–Newman–Keuls test. Abbreviations: ANOVA, analysis of variance; MIF, macrophage migration inhibitory factor; NTS, nucleus of the solitary tract.