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. 2018 Mar 20;15:90. doi: 10.1186/s12974-018-1128-2

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Inhibition of LAR and PTPσ promotes an increase in the subpopulation of M2 macrophages after SCI. a Western blot analysis of Iba1 protein expression at 1, 3, 5, 7, and 14 days following SCI revealed no apparent change in the presence of microglia/macrophage within SCI lesion. b, c Similarly, flow cytometric analysis of spinal cord tissue revealed no change in the total number of infiltrated macrophages (CD45⁺/CD68⁺) at 3 and 7 days post-injury between vehicle control and ILP/ISP (10 μg/day) treated SCI animals. d, e ILP/ISP treatment resulted in a non-significant decrease in the number of CD45⁺/CD68⁺/CD86⁺ M1 macrophages at 3 and 7 days post-injury. f, g A significant increase in the number of CD45⁺/CD68⁺CD163⁺ M2 macrophages was observed at 7 days post-injury in ILP/ISP-treated animals. h Representative flow cytometry gates are depicted. N = 4–6 animals/group/time-point. The data show mean ± SEM, *p < 0.05, one-way ANOVA (a), Student t test (b–g)