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. 2018 Mar 20;15:90. doi: 10.1186/s12974-018-1128-2

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — IL-10 promotes oligodendrocyte differentiation of spinal cord NPCs in vitro. a–c Addition of recombinant IL-10 had no apparent effect on NPCs proliferation (BrdU+/DAPI+) at all doses tested. d However, IL-10 significantly reduced the percentage of GFAP+/DAPI+ astrocytes at 100 and 200 ng/ml, e while increased the percentage of Olig2+ cells at 50, 100, 200, and 400 ng/ml with the highest effect at 200 ng. This effect was significantly attenuated with IL-10 neutralizing antibody. Addition of 0.8 μg/ml of IL10 neutralizing antibody effectively blocked 100 ng/ml of IL-10 on astrocyte and oligodendrocyte differentiation of NPCs. f–k Representative images of NPC differentiation assessment are shown. N = 3–5 independent experiments. The data show the mean ± SEM, *p < 0.05, one-way ANOVA