Table 3.

Pattern of TERT promoter mutations in conjunctival neoplasia and conjunctiva control tissues

TERT mutationsa	Effectb	CIN3 + SCC	CIN1 + CIN2	Control conjunctiva
		N = 41 (%)	N = 31 (%)	N = 53 (%)
− 101G>A	SPI1	3 (7.3)	1 (3.2)	0 (0.0)
− 124G>Ac	ETS	2 (4.9)	2 (6.5)	0 (0.0)
− 124_125GG>AAd	ELK1	4 (9.8)	1 (3.2)	1 (1.9)
− 138_139GG>AAe	ETS	3 (7.3)	2 (6.5)	0 (0.0)
− 146G>Af	ETS	2 (4.9)	3 (9.7)	0 (0.0)
All mutationsg		14 (34.1)	9 (29.0)	1 (1.9)

^aPositions refer to the distance from the ATG start site of TERT gene

^bPutative transcription factors binding sites identified in JASPAR database (http://jaspar.genereg.net)

^cOne sample carried an additional mutation at nt − 101G>A and another at nt − 122G>A (no effect on putative binding sites)

^dOne sample carried an additional mutation at nt − 102G>A (no effect on putative binding sites)

^eOne sample carried two additional mutations at nt − 101G>A and nt − 125G>T with no effect on putative binding sites

^fOne sample carried two additional mutations at nt − 100G>A (no effect on putative binding sites) and nt − 149G>A (creating a putative ETS binding site)

^gΧ² for trend = 16.13, P = 0.00006