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A) The reaction catalyzed by alcohol dehydrogenase (ADH). B) Cartoon representation of one subunit of BsADH (PDB ID: 1RJW),4 showing the substrate analogue trifluoroethanol and cofactor NAD+ in cyan, which are docked based on a homologue (PDB ID: 4GKV).5 The Rossmann fold (red), substrate‐binding domain (purple), and catalytic (green) and structural (yellow) Zn2+ ions are included.
