Table 7.
SN antibody responses.
| IIV4 |
IIV3 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age | Measure | Day | A/H1N1 | A/H3N2 | B Victoria lineage | B Yamagata lineage | A/H1N1 | A/H3N2 | B Victoria lineage | B Yamagata lineage |
| 18–60 y | N | — | 150 | 150 | 150 | 150 | 100 | 100 | 50 | 50 |
| GMT (95% CI) | 0 | 265 (188, 374) | 46.7 (39.1, 55.8) | 96.3 (75.3, 123) | 143 (107, 190) | 238 (159, 356) | 43.8 (36.5, 52.5) | 111 (71.2, 174) | 188 (125, 281) | |
| 21 | 3540 (2997, 4183) | 215 (182, 254) | 1143 (952, 1373) | 1825 (1463, 2277) | 3076 (2308, 4100) | 307 (239, 395) | 1269 (875, 1841) | 1680 (1164, 2423) | ||
| GMTR (95% CI) | 21/0 | 13.4 (9.61, 18.6) | 4.60 (3.81, 5.56) | 11.9 (9.24, 15.2) | 12.8 (9.64, 17.0) | 12.9 (8.89, 18.8) | 7.01 (5.29, 9.30) | 11.4 (7.08, 18.3) | 8.95 (5.96, 13.4) | |
| ≥4-fold rise, n (%) | 21/0 | 61.3 (53.0, 69.2) | 47.3 (39.1, 55.6) | 70.0 (62.0, 77.2) | 67.3 (59.2, 74.8) | 62.0 (51.7, 71.5) | 59.0 (48.7, 68.7) | 66.0 (51.2, 78.8) | 68.0 (53.3, 80.5) | |
| ≥60 y | N | — | 150 | 150 | 150 | 149 | 98 | 98 | 49 | 49 |
| GMT (95% CI) | 0 | 137 (101; 187) | 48.7 (39.7; 59.7) | 114 (88.7; 147) | 124 (97.1; 158) | 154 (101; 234) | 58.5 (44.7; 76.5) | 109 (78.2; 151) | 136 (85.0; 218) | |
| 21 | 988 (763; 1279) | 179 (151; 212) | 509 (414; 625) | 572 (465; 704) | 1196 (902; 1584) | 192 (149; 246) | 559 (391; 799) | 523 (370; 738) | ||
| GMTR (95% CI) | 21/0 | 7.19 (5.59; 9.24) | 3.67 (3.00; 4.50) | 4.46 (3.60; 5.53) | 4.68 (3.67; 5.96) | 7.76 (5.38; 11.2) | 3.28 (2.57; 4.17) | 5.14 (3.34; 7.93) | 3.84 (2.57; 5.74) | |
| ≥4-fold rise, n (%) | 21/0 | 54.7 (46.3; 62.8) | 33.3 (25.9; 41.5) | 42.7 (34.6; 51.0) | 41.6 (33.6; 50.0) | 52.0 (41.7; 62.2) | 34.7 (25.4; 45.0) | 36.7 (23.4; 51.7) | 34.7 (21.7; 49.6) | |
Values are for all participants with pre- and post-vaccination seroneutralization titers available. Abbreviations: CI, confidence interval; GMT, geometric mean SN titer; GMTR, geometric mean of the individual ratios of the post-vaccination (day 21) SN titer divided by the pre-vaccination (day 0) SN titer; IIV3, trivalent inactivated influenza vaccine; IIV4, quadrivalent inactivated influenza vaccine; NC, not calculable; SN, seroneutralizing.