Table 1.

Comparison of Criteria Used for Frailty Phenotype Assessments Clinically and in Mice

	Human Frailty Phenotype Assessment	Mouse Frailty Phenotype Assessment	Modified Mouse Frailty Phenotype Assessment
Reference	Fried et al. (5)	Liu et al. (17)	Current study
Cutoff value	Lowest 20% of cohort	1.5 SD below cohort mean (approximately lowest 7%)	0.8 SD below cohort mean (approximately lowest 20%)
Criteria	Grip strength	Four paw inverted hang (seconds to fall)	Front paw wire hang (seconds to fall)
	Activity	Voluntary wheel running (daily running distance)	Open-field assessment (distance moved in 5 min)
	Walking speed	Rotarod - training protocol (maximum speed)	Rotarod - no training protocol (maximum speed)
	Endurance	Derived from four paw hang and rotarod measures (seconds)	Derived from wire hang and rotarod measures (seconds)
	Weight loss	Not included	Low body weight

Note: SD = standard deviation.