Table 2.

Associations Between European American and African American Race With Brain Volumes on Cerebral MRI

Variable	Covariate	β (95% CI)*	p-Value
White matter volume	TICV, MRI scanner	−12.65 (−19.76, −5.54)	.0005
White matter volume	Above + age, sex, diabetes duration	−12.54 (−19.85, −5.24)	.0008
White matter volume	Above + BMI, HbA1c	−13.01 (−20.50, −5.52)	.0007
White matter volume	Above + statins, CVD, smoking, hypertension	−12.70 (−20.34, −5.06)	.0011
Gray matter volume	TICV, MRI scanner	12.97 (3.79, 22.16)	.0056
Gray matter volume	Above + age, sex, diabetes duration	4.32 (−2.55, 11.18)	.2179
Gray matter volume	Above + BMI, HbA1c	4.44 (−2.72, 11.60)	.2241
Gray matter volume	Above + statins, CVD, smoking, hypertension	3.89 (−3.41, 11.18)	.2963
White matter lesion volume	TICV, MRI scanner	2.35 (−0.40, 5.10)	.0940
White matter lesion volume	Above + age, sex, diabetes duration	4.27 (1.62, 6.92)	.0016
White matter lesion volume	Above + BMI, HbA1c	4.21 (1.49, 6.93)	.0024
White matter lesion volume	Above + statins, CVD, smoking, hypertension	4.49 (1.77, 7.22)	.0012
Hippocampal GMV	TICV, MRI scanner	0.27 (0.02, 0.51)	.0336
Hippocampal GMV	Above + age, sex, diabetes duration	0.06 (−0.16, 0.28)	.6016
Hippocampal GMV	Above + BMI, HbA1c	0.02 (−0.20, 0.25)	.8316
Hippocampal GMV	Above + statins, CVD, smoking, hypertension	0.01 (−0.21, 0.24)	.9138

^*Notes: African American:European American regression coefficient and 95% Confidence Interval.

BMI = Body mass index; CVD = cardiovascular disease; GMV = Gray matter volume; HbA1c = Hemoglobin A1c; MRI = Magnetic resonance imaging; TICV = Total intracranial volume.

European Americans were the reference group.