Table 3.

Association of Negative Affect With Incidence of Probable Dementia and Cognitive Impairment

	Positive Affect						Negative Affect
	MCI			Probable Dementia			MCI			Probable Dementia
	Hazard Ratio	95% CI	p Value	Hazard Ratio	95% CI	p Value	Hazard Ratio	95% CI	p Value	Hazard Ratio	95% CI	p Value
Model 1	0.90	(.71, 1.14)	.4	0.94	(.74, 1.19)	.6	1.54	(1.23, 1.94)	.0002	1.34	(1.04, 1.72)	.02
Model 2	0.99	(.78, 1.26)	.95	1.05	(.82, 1.35)	.68	1.64	(1.30, 2.08)	<.0001	1.44	(1.11, 1.86)	.005
Model 3	0.99	(.78, 1.26)	.92	1.06	(.83, 1.37)	.63	1.70	(1.35, 2.15)	<.0001	1.38	(1.06, 1.80)	.02
Model 4	0.99	(.78, 1.25)	.93	1.03	(.81, 1.32)	.8	1.55	(1.21, 1.99)	.0006	1.33	(1.01, 1.76)	.04

Note: Model 1 is the unadjusted model showing the hazard ratios associated with PA and NA (per 10-unit increment on PANAS). Model 2 adjusted for demographic factors (age, race, education), and randomization arm. Model 3 adjusted for all Model 2 variables as well as lifestyle factors (marital status, smoking status, alcohol consumption, exercise). Model 4 is the fully adjusted model that includes all demographic, lifestyle, and health variables listed in Table 1. MCI = Mild cognitive impairment.