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. 2017 Jun 20;73(1):11–20. doi: 10.1093/gerona/glx119

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© The Author(s) 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 5. — Tyrosine hydroxylase (TH) protein expression and ser³¹ TH phosphorylation. (A) Striatum, total TH. There was a significant difference in TH protein across all groups (one-way ANOVA, F_(2,37) = 3.83, p < .05). TH protein expression was significantly less in the calorie restriction (CR) group compared with the AL and 12-month control group. Post hoc (12-month control vs AL, t = 0.04, ns; *12-month control vs CR, t = 2.25, p < .05; *AL vs CR, t = 2.45, p < .05). (B) Striatum, ser³¹ TH phosphorylation. ser³¹ phosphorylation TH protein was significantly increased in the CR group versus 12-month-old control group. One-way analysis of variance (ANOVA; F_(2,37) = 3.16, p = .054), (post hoc 12-month control vs CR, t = 2.48, p < .05; AL vs 12-month control, t = 1.64, ns; AL vs CR, t = 0.88, ns). (C) Substantia nigra, total TH. TH protein expression was significantly greater in the CR group compared with the AL group. One-way ANOVA (F_(2,37) = 2.73, p = .08), (post hoc 12-month control vs AL, t = 0.70, p = .49; 12-month control vs CR, t = 1.44, p = .17; *AL vs CR, t = 2.29, p < .05). (D) Substantia nigra, ser³¹ TH phosphorylation. No significant differences in ser³¹ TH phosphorylation were observed among the three groups. One-way ANOVA (F_(2,37) = 0.01, p = .99), (post hoc 12-month control vs AL, t = 0.08, ns; 12-month control vs CR, t = 0.03, ns; AL vs CR, t = 0.12, ns).