Table 1.
Baseline Characteristics of Overall Study Population and OPUS Versus OPEL
| Description | Overall (n = 984) | OPEL (n = 448) | OPUS (n = 536) | p-value |
|---|---|---|---|---|
| Age, mean (1st–3rd quartile) | 76.07 (70.61–80.53) | 74.84 (70.17–78.32) | 77.09 (70.88–81.68) | <.001 |
| Sex (% female), n (%) | 545 (55.4) | 269 (60.0) | 276 (51.8) | .008 |
| Education (years), mean ± SD | 17.28 ± 2.97 | 17.57 ± 2.90 | 17.03 ± 3.01 | .005 |
| Body Mass Index, mean ± SD | 27.84 ± 6.53 | 28.37 ± 8.24 | 27.40 ± 4.59 | .021 |
| Blessed-Information-Memory Concentration test, mean ± SD (range 0–32) | 1.13 ± 1.44 | 0.95 ± 1.29 | 1.27 ± 1.53 | .001 |
| Gait speed (cm/s), mean ± SD | 108.93 ± 20.18 | 112.12 ± 18.81 | 106.30 ± 20.89 | <.001 |
| Repeated chair rise time (s), mean ± SD | 10.63 ± 3.64 | 10.32 ± 3.44 | 11.30 ± 3.77 | <.001 |
| Unipedal stance time (s), mean ± SD | 15.90 ± 12.07 | 17.12 ± 10.65 | 13.21 ± 10.55 | <.001 |
| SPPBa score, mean ± SD | 8.58 ± 2.30 | 9.00 ± 2.21 | 8.21 ± 2.31 | <.001 |
| Grip strength (kg), mean ± SD | 12.42 ± 11.28 | 12.02 ± 10.98 | 12.76 ± 11.52 | .307 |
| Global health summary, mean ± SD | 1.30 ± 1.08 | 1.19 ± 1.07 | 1.39 ± 1.08 | .003 |
| Depression, n (%) | 181 (18.4) | 83 (18.8) | 98 (18.5) | .934 |
| Diabetes, n (%) | 90 (9.1) | 33 (7.4) | 57 (10.7) | .095 |
| Heart Failure, n (%) | 11 (1.1) | 3 (0.7) | 8 (1.5) | .362 |
| Hypertension, n (%) | 433 (44.0) | 164 (39.6) | 269 (52.6) | <.001 |
| Myocardial Infarction, n (%) | 60 (6.1) | 21 (4.7) | 39 (7.3) | .108 |
| Angina, n (%) | 32 (3.3) | 16 (3.7) | 16 (3.1) | .587 |
| Stroke, n (%) | 38 (3.9) | 7 (1.6) | 31 (5.8) | .001 |
| Parkinson’s Disease, n (%) | 14 (1.4) | 5 (1.1) | 9 (1.7) | .592 |
| Chronic Obstructive Lung Disease, n (%) | 34 (3.5) | 13 (2.9) | 21 (3.9) | .484 |
| Arthritis, n (%) | 377 (38.3) | 181 (41.0) | 196 (36.8) | .187 |
Notes: OPUS = offspring of parents with usual survival; OPEL = offspring of parents with exceptional longevity.
aShort Physical Performance Battery.