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. 2016 Oct 27;72(8):1045–1053. doi: 10.1093/gerona/glw192

Figure 1.

Figure 1.

BDA-410 treatment induced loss of weight and body fat but not lean mass in mice. Baseline (A) and change (B) in mouse body (n = 8 vehicle, n = 9 BDA-410; *p = .01). (C) Change in body fat measured by dual-energy X-ray absorptiometry scans (n = 8 vehicle, n = 9 BDA-410; *p = .042). (D) Representative dual-energy X-ray absorptiometry scans of a BDA-410-treated mouse that lost 28% of its body fat. Dotted lines denote the thickness of subcutaneous WAT in the flank (n = 4). (E) Perigonadal fat weight in BDA-410- (n = 5) and vehicle-treated mice (p < .05). (F) Oil-red-O staining of soleus muscle from BDA-410- and vehicle-treated mice. (G) Lung, heart, spleen, kidney, liver, and soleus muscle weight and serum nonesterified fatty acids concentration in BDA-410- (n = 5) and vehicle-treated (n = 5) mice.