Figure 5.

Schematic representation of differentially expressed genes in the skeletal muscle of old, sedentary C57BL/6 mice after BDA-410 treatment. This scheme shows several signaling cascades and the corresponding metabolic pathways involved in skeletal muscle-adipose tissue crosstalk. The plus (+) and minus (−) signs represent upregulated and downregulated genes, respectively, in BDA-treated mice compared to vehicle-treated mice. Arrows show positive regulation, whereas truncated lines represent an inhibitory action or effect. TG = triglycerides; NEFA/LCFA = nonesterified fatty acids/long-chain fatty acids; VLD = very-low-density lipoprotein.