Figure 1.

Flow diagram of study participants throughout CROSSROADS trial. *Immediately following randomization and prior to receipt of intervention, three participants were diagnosed with cancer. Because cancer is an exclusion criterion and because we believe these participants very likely had undiagnosed cancer at the time of randomization, in the spirit of a controlled randomized trial and intention-to-treat, we do not include these three persons in any of our analyses. *Lost to follow-up and withdrew indicate those individuals for whom 12-month follow-up data were not collected.