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. 2017 Jun 30;72(12):1614–1619. doi: 10.1093/gerona/glx118

Figure 1.

Figure 1.

Life span of wild-type (WT) C. elegans strain exposed to various conc. of UA. The 25 µM test concentration showed the most significant increase in life span (31.3%, p < .001). DMSO (0.05%) was taken as control (0 µM UA) for all the experiments. Life span assay was performed at 20°C. Survival plots were drawn by Kaplan–Meier survival assay. (B) UA treatment resulted in longer reproductive span (MRS) on control is 2.3 ± 0.44 days on 25 µM UA is 3.9 ± 0.67 days; p = .0247 with small brood size (inset; brood size for 0 µM UA is 290.5 ± 2.5 while for 25 µM UA is 266.0 ± 2.0; p = 0.0381) (C) The lower and delayed accumulation of lipofuscin in the intestine indicates better health span; scale bars, 100 µm. Right panel represents quantification of the mean fluorescence (47.07%, p = 0.0018 in adult day 5 animals) using imageJ.