. 2017 Sep 1;4(1):59–68. doi: 10.1093/ehjqcco/qcx032

Table 4.

Multivariate analysis for variables associated with clinical events

	Thromboembolism		Major haemorrhage		All-cause death		Cardiovascular death		Composite events^a
	HR	P-value	HR	P-value	HR	P-value	HR	P-value	HR	P-value
	(95% CI)	P-value	(95% CI)	P-value	(95% CI)	P-value	(95% CI)	P-value	(95% CI)	P-value
CrCl <30 mL/min^b	1.69	0.309	1.37	0.441	6.44	<0.001	3.99	0.017	2.99	<0.001
CrCl <30 mL/min^b	(0.62–4.62)	0.309	(0.62–3.03)	0.441	(3.03–13.7)	<0.001	(1.28–12.4)	0.017	(1.91–4.67)	<0.001
CrCl 30–49.9 mL/min^b	2.27	0.029	1.10	0.775	3.14	0.002	2.29	0.126	1.94	0.001
CrCl 30–49.9 mL/min^b	(1.09–4.72)	0.029	(0.58–2.09)	0.775	(1.54–6.41)	0.002	(0.79–6.61)	0.126	(1.31–2.88)	0.001
CrCl 50–79.9 mL/min^b	1.99	0.030	0.91	0.747	1.73	0.111	0.71	0.523	1.40	0.058
CrCl 50–79.9 mL/min^b	(1.07–3.72)	0.030	(0.53–1.58)	0.747	(0.88–3.38)	0.111	(0.25–2.04)	0.523	(0.99–1.99)	0.058
Heart failure	1.14	0.545	1.44	0.063	2.90	<0.001	5.98	<0.001	1.80	<0.001
Heart failure	(0.75–1.73)	0.545	(0.98–2.12)	0.063	(2.06–4.08)	<0.001	(3.06–11.71)	<0.001	(1.46–2.22)	<0.001
Hypertension	1.04	0.309	1.46	0.070	0.66	0.011	0.54	0.024	0.95	0.602
Hypertension	(0.70–1.54)	0.309	(0.97–2.19)	0.070	(0.48–0.91)	0.011	(0.31–0.92)	0.024	(0.77–1.17)	0.602
Age ≥75 years	1.67	0.113	2.65	0.004	2.80	0.002	2.03	0.201	2.37	<0.001
Age ≥75 years	(0.88–3.16)	0.113	(1.36–5.17)	0.004	(1.44–5.44)	0.002	(0.69–6.03)	0.201	(1.62–3.45)	<0.001
Diabetes mellitus	2.00	0.444	1.12	0.602	1.17	0.397	1.57	0.135	1.15	0.241
Diabetes mellitus	(0.75–1.90)	0.444	(0.73–1.72)	0.602	(0.81–1.69)	0.397	(0.87–2.83)	0.135	(0.91–1.47)	0.241
Stroke/TIA	1.56	0.064	1.60	0.030	1.52	0.029	1.18	0.645	1.55	<0.001
Stroke/TIA	(0.97–2.50)	0.064	(1.05–2.46)	0.030	(1.04–2.20)	0.029	(0.59–2.36)	0.645	(1.22–1.97)	<0.001
Vascular diseases	0.92	0.791	1.14	0.622	1.76	0.005	1.58	0.185	1.34	0.036
Vascular diseases	(0.50–1.71)	0.791	(0.68–1.91)	0.622	(1.19–2.61)	0.005	(0.80–3.10)	0.185	(1.02–1.77)	0.036
Age 65–74 years	0.99	0.961	1.59	0.144	1.39	0.331	1.41	0.521	1.31	0.143
Age 65–74 years	(0.53–1.82)	0.961	(0.85–2.98)	0.144	(0.72–2.70)	0.331	(0.49–4.06)	0.521	(0.91–1.89)	0.143
Female	0.80	0.303	0.60	0.026	0.48	<0.001	0.80	0.448	0.59	<0.001
Female	(0.52–1.23)	0.303	(0.38–0.94)	0.026	(0.33–0.71)	<0.001	(0.44–1.44)	0.448	(0.47–0.76)	<0.001
Warfarin at baseline	0.45	0.001	2.54	0.030	0.57	0.013	0.58	0.175	0.73	0.037
Warfarin at baseline	(0.27–0.73)	0.001	(1.10–5.90)	0.030	(0.36–0.89)	0.013	(0.26–1.28)	0.175	(0.54–0.98)	0.037
Antiplatelet use	0.98	0.943	1.44	0.089	1.05	0.778	1.31	0.395	1.14	0.281
Antiplatelet use	(0.62–1.55)	0.943	(0.95–2.20)	0.089	(0.73–1.52)	0.778	(0.71–2.42)	0.395	(0.90–1.44)	0.281

Vascular disease = coronary artery disease.

CrCl, creatinine clearance; HR, hazard ratio; CI, confidence interval; TIA, transient ischaemic attack.

^aThromboembolism, major haemorrhage, and all-cause death.

^bVersus CrCl ≥80 mL/min.