Table 2.

Early (≤30 days) outcomes related to frailty in included studies

Author, year	Outcome(s) related to frailty	Adjustment	Effect estimatea	Lower 95% CI	Upper 95% CI	P-value
Stortecky, 201235	30-day MACCE	Nil	4.78	0.96	23.77	0.05
	30-day MAACE (per unit increase in frailty index)	Nil	1.66	1.14	2.44	0.01
	30-day all-cause mortality	Nil	8.33	0.99	70.48	0.03
	30-day all-cause mortality (per unit increase in frailty index)	Nil	2.18	1.32	3.61	0.002
Puls, 201438	All-cause mortality	Nil	3.05	1.4	5.7	0.003
	Procedural myocardial infarction	Nil	1.08	0.15	7.59	0.94
	Procedural major stroke	Nil	0.98	0.41	2.33	0.95
	Procedural TIA	Nil	1.08	0.07	17.16	0.95
	Life-threatening or disabling bleeding	Nil	0.86	0.45	1.62	0.63
	Major bleeding	Nil	2.17	0.84	5.62	0.11
	Minor bleeding	Nil	1.50	1.05	2.16	0.03
	Renal failure requiring dialysis	Nil	2.01	1.09	3.70	0.02
Capodanno, 201440	All-cause mortality	Nil	2.09	1.30	3.37	0.003
Green, 201542	All-cause mortality	Nil	1.34	0.59	3.04	0.48
	Cardiovascular mortality	Nil	1.22	0.47	3.14	0.68
	Major stroke	Nil	0.61	0.06	6.63	0.68
	Major bleeding	Nil	1.74	0.69	4.42	0.24
	Major vascular complications	Nil	1.42	0.49	4.11	0.52
	Permanent pacemaker insertion	Nil	1.02	0.46	2.26	0.97
	Renal failure requiring dialysis	Nil	1.57	0.60	4.07	0.36

MAACE, major adverse cardiovascular and cerebral events.

^aWhere not presented directly by authors, relative risk ratios calculated from two-by-two tables for those with and without frailty.