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. 2017 Dec 1;10:131–141. doi: 10.1016/j.omtn.2017.11.014

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Proposed Exosomes’ Role in BC Resistance to Therapy

(A) Tamoxifen-resistant BC cells (LCC2 cell line) secrete UCA1-overexpressed exosomes, which can cause resistance to tamoxifen (TAM) treatment of the MCF7 cell line and decrease apoptosis through reduction of cleaved caspase-3 expression. (B) RAB27B-upregulated stromal cells release exosomes that contain 5′-triphosphate RNAs and activate STAT1-dependent antiviral signaling and NOTCH3 pathways in adjacent BC cells. The crosstalk between these two signaling pathways results in reduction of chemo-resistance and radiotherapy (RT) resistance in different BC cell lines.