Table 3.
IC50 of Aptamer-Toxin Conjugates on PDAC Cell Lines
| Toxin (nM) | C36 (nM) | Waz (nM) | E07 (nM) | ||
|---|---|---|---|---|---|
| Panc-1 | MMAE | 11 (8.9–13) | 110 (76–148) | 35 (31–41) | 55 (44–69) |
| MMAF | 140 (110–190) | >1,000 | 190 (130–280) | >1,000 | |
| MIA PaCa-2 | MMAE | 7.5 (6.5–8.7) | 290 (250–340) | 37 (33–41) | 130 (90–190) |
| MMAF | 290 (260–340) | 940 (190–>1,000) | 51 (49–53) | 220 (200–240) | |
| BxPC3 | MMAE | 16 (15–18) | 220 (200–240) | 39 (37–41) | 110 (100–120) |
| MMAF | 290 (0–320) | >1,000 | 450 (410–530) | >1,000 (480–>1,000) | |
| B16 | MMAE | 56 (46–69) | >1,000 | >1,000 | >1,000 |
| MMAF | >1,000 | >1,000 | >1,000 | >1,000 |
The IC50 values of aptamer-toxin conjugates, nontargeting control-toxin conjugates, and toxin alone on PDAC cells lines are reported in nanomolars, including the 95% confidence interval. Results are based on three discrete measurements at each concentration.