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. Author manuscript; available in PMC: 2018 Mar 21.
Published in final edited form as: Neuroscience. 2014 Jul 11;277:250–266. doi: 10.1016/j.neuroscience.2014.07.006

Fig. 9. Bidirectional modulations of DCN cell bursting by photostimulation-induced GABA release.

Fig. 9

A. A regular firing pattern persists under photo stimulation of 3 pulses at 20 Hz, delivered every 2s. However, upon removal of photostimulation the duration of the bursts lengthens (left). Time-expanded panels (middle, right) show that the laser pulses induce IPSPs (arrowheads) during up-states but EPSPs (arrows) during down-states. B. Bar graph of electrical behavior in bistable cells, showing that the length of the down-state is unaffected by tonic photostimulation, while the up-state's duration is significantly increased without light-activated inhibition. C. Examples of photostimulation-induced, GABA-mediated postsynaptic currents obtained at various holding potentials (shown on the left) in a DCN cell under perforated patch. The reversal potential for this cell was -58 mV. Note the delay (∼5 ms) between the laser pulse and onset of current responses. D. I-V curves of three DCN cells, including the cell shown in E, with reversal potentials ranging from -58 to -62 mV.