Table 3.
Detection and overdiagnosis of DCIS and invasive disease across the CISNET models for biennial screening from age 50-74 years.
| Model | DCIS dx per 1000 | DCIS overdx per 1000 | %overdx DCIS | invasive dx per 1000 | invasive overdx per 1000 | %overdx invasive | total dx per 1000 | overdx per 1000 | %overdx (DCIS + invasive) |
|---|---|---|---|---|---|---|---|---|---|
| D | 30.2 | 15.5 | 51.3% | 128.3 | 3.3 | 2.6% | 158.5 | 18.8 | 11.9% |
| E | 25.8 | 16.1 | 62.4% | 131.8 | 2.0 | 1.5% | 157.6 | 18.1 | 11.5% |
| GE | 26.7 | 9.0 | 33.7% | 110.7 | 1.8 | 1.6% | 137.4 | 10.8 | 7.9% |
| M | 26.2 | 18.8 | 71.8% | 128.2 | 15.4 | 12.0% | 154.4 | 34.2 | 22.2% |
| W | 32.3 | 15.6 | 48.3% | 114.8 | 9.9 | 8.6% | 147.1 | 25.5 | 17.3% |
|
| |||||||||
| Median | 26.7 | 15.6 | 51.3% | 128.2 | 3.3 | 2.6% | 154.4 | 18.8 | 11.9% |
Model D: Dana-Farber Cancer Institute, Boston, Massachusetts. Model E: Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Model GE: Georgetown University Medical Center, Washington, DC, and Albert Einstein College of Medicine, Bronx, New York. Model M: MD Anderson Cancer Center, Houston, Texas. Model W: University of Wisconsin-Madison, Madison, Wisconsin, and Harvard Medical School, Boston, Massachusetts.