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. 2018 Mar 8;9(1):21–28. doi: 10.14740/wjon1088w

Figure 3.

Figure 3

Effect of inhibition of ERK1/2, AKT and JNK pathways prior to 2.0 Gy radiation exposures of B16F10 cells. B16F10 cells were treated with 20 µM concentrations of U0126, LY294002 and SP600125, 24 h before exposing cells to 2.0 Gy of radiation. Pink color indicates viable cell fraction and green color indicates dead cell fraction. Cell death in U0126 + 2.0 Gy group versus 2.0 Gy alone: P < 0.0001; cell death in LY294002 + 2.0 Gy group versus 2.0 Gy alone: P < 0.0001; cell death in SP600125 + 2.0 Gy group versus 2.0 Gy alone: P < 0.01; cell death in U0126 + LY29400 + 2.0 Gy versus 2.0 Gy alone: P < 0.001.