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. 2018 Mar 8;9(1):21–28. doi: 10.14740/wjon1088w

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Copyright 2018, Kalal et al.

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increase in amount of cell death (%) with inhibitors of ERK1/2, AKT and JNK pathways. Inhibition of either ERK1/2 or AKT pathways enhanced radiation-induced cell death almost equally (about 43% at 2.0 Gy and about 55% at 3.0 Gy), while inhibition of JNK enhanced relatively low amount of cell death (about 12%) at 2.0 Gy as well as at 3.0 Gy. Combined inhibition of U0126 + LY294002 prior to radiation treatment enhanced radiation induced cell death at 2.0 Gy by 45% and at 3.0 Gy by 51%. Overall no significant difference in percent increase in cell death was observed between U0126, LY294002 or their combination both with 2.0 Gy and 3.0 Gy treatments.