Table 1.

Clinical and EEG features of patients

	Patients/sex/age	Reactivity			Outcomea	GPEDs frequency (Hz)	GPEDs Amplitude (uV)
		Anti‐seizure manoeuver	EEG response	Clinical Response
Group 1
Patient 1	1 / F / 52	None	N/A	N/A	3	2.5–3.0	−275.6
Patient 2	2 / M / 55	DZP	GPEDs ceased; θ, α and β	Opened eyes to command	2	2.5–3.0	−187
Group 2
Patient 3	3 / M / 63	LRZ	GPEDs ceased; δ, θ, α and β	No	3	1.5–2	−55.69
Patient 4	4 / M / 62	CNZ	GPEDs ceased; δ and θ	No	3	0.8–1.5	−34.8
Patient 5	5 / M / 60	Propofol window	GPEDs ceased; δ and θ, some α	No	5	1	−110.7
Patient 6	6 / M / 60	None	N/Ab	No response	3	1.2–2.0	−83
Patient 7	7 / M / 71	DZP	GPEDs ceased; δ and θ, some α	No	3	1.2–1.8	−130.6
Patient 8	8 / M / 70	Propofol window	No physiological rhythms, but focal frontal seizure activity	No	5	0.8–1.2	−74.8
Group 3
Patient 9	8 / M / 58	LRZ	No Effect	No response	3	1.5–2.0	−86.4
Patient 10	9 / M / 78	LRZ	No Effect	No response	5	0.7–1.5	−242.5
Patient 11	10 / M / 36	MDZ	N/A	No response	5	1–1.5	−174.3
Patient 12	11 / M / 33	Propofol window	No Effect	No response	5	1–1.5	−221.5
Patient 13	13 / M / 81	Propofol window	No Effect	No response	5	1.6–1.8	−62.7

DZP, diazepam; LRZ, lorazepam; CNZ, clonazepam; MDZ, midazolam; GPED, generalized periodic epileptiform discharges.

^aGlasgow‐Pittsburgh Cerebral Performance Categories.

^bComplete resolution of GPEDs with emergence of θ and α rhythms was recorded two days later after AED increased from LEV 500bd IV to LEV 1500bd and VPA 300bd, both IV.