Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 19;2(3):355–359. doi: 10.1002/epi4.12067

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The effect of IgG on UP state duration and spike rate. (A–C) Effect of HC IgG (100 μg/mL) on UP states. Representative image showing UP state duration and spike rate are unaffected following the application of HC IgG. Top panel: UP state recordings taken during baseline recordings in aCSF. Middle panel: HC IgG (100 μg/mL). Bottom panel: following aCSF wash. LIII; Layer III, Stim; Stimulation (A). Following application of HC IgG, UP state duration and spike rate were unaffected (pooled data from 4 slices) (B and C). (D–F) Effect of test IgG (GABA_BR patient IgG) on UP states. Representative image showing both UP state duration and the spike rate were significantly reduced following the application of patient IgG. Top panel: UP state recordings taken during baseline recordings in aCSF. Middle panel: test IgG (100 μg/mL). Bottom panel: following aCSF wash. LIII; Layer III, Stim; Stimulation (D). UP state duration was significantly reduced following the application of test IgG (**p = 0.0028, pooled data n = 6) (E). Similarly, a significant reduction was noted in spikes present during UP state events following application of test IgG (*p = 0.0185, pooled data n = 5) (F).