Table 6.

Cox proportional hazards model for discontinuation due to adverse events by lacosamide treatment group in subjects with diabetic neuropathic pain

	Hazard ratio (95% CI)	p Value
Lacosamide 200 mg/day
Age (≥ 65 vs. <65 years)	0.825 (0.333,1.873)	0.6576
Number of concomitant diseases	1.039 (0.954,1.104)	0.2980
Number of concomitant medications	0.979 (0.890,1.058)	0.6334
Sex (female vs. male)	0.902 (0.396,1.990)	0.7994
Years with diabetic neuropathy	1.016 (0.775,1.320)	0.9072
Lacosamide 400 mg/day
Age (≥65 vs. < 65 years)	2.315 (1.591,3.355)	<.0001
Number of concomitant diseases	1.111 (1.069,1.152)	<.0001
Number of concomitant medications	0.978 (0.929,1.029)	0.4044
Sex (female vs. male)	1.349 (0.938,1.950)	0.1077
Years with diabetic neuropathy	1.077 (0.998,1.149)	0.0396
Lacosamide 600 mg/day
Age (≥65 vs. < 65 years)	2.735 (1.879,3.942)	<.0001
Number of concomitant diseases	1.047 (1.004,1.090)	0.0265
Number of concomitant medications	1.012 (0.968,1.056)	0.5771
Sex (female vs. male)	1.526 (1.070,2.181)	0.0196
Years with diabetic neuropathy	0.977 (0.885,1.059)	0.6115

CI, confidence interval.