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KD and Biostability (T1/2) of TBA and TBA Variants Modified with Canonical UNAs (AU, CU, GU) and UNA-s4U (s4UU)
| Position of Modification | Sequence (5ʹ-3ʹ) | KD (nM) | T1/2 (s) |
|---|---|---|---|
| GGTTGGTGTGGTTGG | 4.23 | 59.3 | |
| T3 | GGAUTGGTGTGGTTGG | 5.99 | ND |
| T7 | GGTTGGAUGTGGTTGG | 4.75 | 78.9 |
| T7 | GGTTGGCUGTGGTTGG | 4.39 | 89.2 |
| T7 | GGTTGGGUGTGGTTGG | 4.25 | 89.2 |
| T9 | GGTTGGTGCUGGTTGG | 8.77 | ND |
| T12 | GGTTGGTGTGGAUTGG | 10.91 | ND |
| T3 | GGs4UUTGGTGTGGTTGG | 6.67 | ND |
| T7 | GGTTGGs4UUGTGGTTGG | 5.00 | 66.9 |
| T12 | GGTTGGTGTGGs4UUTGG | 15.99 | ND |
ND, not determined.
