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. 2017 Dec 30;10:331–348. doi: 10.1016/j.omtn.2017.12.014

Figure 8.

Figure 8

circ-SHKBP1 Knockdown Combined with miR-544a/miR-379 Overexpression Suppressed Angiogenesis In Vivo

(A) The co-effect of circ-SHKBP1 and miR-544a on the angiogenesis in vivo was evaluated by Matrigel plug assay. (B) The amount of hemoglobin was measured after combination of circ-SHKBP1 and miR-544a. Data represent the means ± SD (n = 5, each group). *p < 0.05, **p < 0.01 versus the circ-SHKBP1 (−) NC + miR-544a (+) NC group; #p < 0.05 versus the circ-SHKBP1 (−) group; &p < 0.05 versus the miR-544a (+) group. (C) The co-effect of circ-SHKBP1 and miR-379 on the angiogenesis in vivo was detected by Matrigel plug assay. (D) The amount of hemoglobin was measured after combination of circ-SHKBP1 and miR-379. Data represent the means ± SD (n = 5, each group). *p < 0.05, **p < 0.01 versus the circ-SHKBP1 (−) NC + miR-379 (+) NC group; #p < 0.05 versus the circ-SHKBP1 (−) group; &p < 0.05 versus the miR-379 (+) group. (E) The schematic cartoon underlying the mechanism of circ-SHKBP1 on the angiogenesis of GECs.