Table 2.
Relationship between brain abnormality scores and suboptimal neurobehaviour
| Suboptimal neurobehaviour | Global brain abnormality score OR (95% CI), p Value |
Cerebral WM brain abnormality score OR (95% CI), p Value |
Cortical grey matter abnormality score OR (95% CI), p Value |
Deep nuclear grey matter abnormality score OR (95% CI), p Value |
Cerebellar abnormality score OR (95% CI), p Value |
| NNNS attention | 1.03 (0.87 to 1.21), 0.67 | 1.18 (0.91 to 1.53), 0.20 | 0.75 (0.50 to 1.13), 0.16 | 1.59 (0.42 to 5.95), 0.50 | 1.08 (0.61 to 1.90), 0.80 |
| NNNS arousal | 0.93 (0.82 to 1.04), 0.21 | 0.89 (0.72 to 1.09), 0.26 | 1 (0.77 to 1.28), 0.98 | 0.74 (0.29 to 1.92), 0.54 | 0.77 (0.48 to 1.25), 0.30 |
| NNNS regulation | 0.99 (0.89 to 1.11), 0.88 | 1.01 (0.84 to 1.21), 0.94 | 0.98 (0.76 to 1.27), 0.90 | 0.21 (0.03 to 1.30), 0.09 | 1.01 (0.69 to 1.47), 0.97 |
| NNNS handling | 0.85 (0.68 to 1.07), 0.16 | 0.72 (0.42 to 1.23), 0.23 | 1.08 (0.78 to 1.51), 0.65 | Omitted* | 0.51 (0.18 to 1.44), 0.20 |
| NNNS quality of movement | 1.07 (0.94 to 1.21), 0.31 | 1.07 (0.87 to 1.32), 0.51 | 1.02 (0.78 to 1.34), 0.88 | 0.44 (0.11 to 1.70), 0.23 | 1.45 (0.97 to 2.16), 0.07 |
| NNNS excitability | 0.93 (0.83 to 1.05), 0.25 | 0.87 (0.71 to 1.06), 0.17 | 1.05 (0.83 to 1.35), 0.67 | 0.20 (0.03 to 1.50), 0.12 | 0.85 (0.57 to 1.27), 0.43 |
| NNNS lethargy | 1.20 (1.01 to 1.43), 0.04 | 1.44 (1.09 to 1.89), 0.01 | 0.78 (0.47 to 1.27), 0.32 | Omitted* | 2.22 (1.38 to 3.59),<0.01 |
| NNNS non-optimal reflexes | 1.23 (1.07 to 1.41),<0.01 | 1.30 (1.06 to 1.59), 0.01 | 1.33 (1.03 to 1.72), 0.03 | 1.12 (0.36 to 3.53), 0.85 | 1.47 (0.97 to 2.23), 0.07 |
| NNNS asymmetrical reflexes | 0.86 (0.69 to 1.08), 0.20 | 0.89 (0.63 to 1.26), 0.52 | 0.83 (0.50 to 1.36), 0.45 | Omitted* | 0.43 (0.18 to 1), 0.05 |
| NNNS hypertonicity | 1.07 (0.92 to 1.24), 0.40 | 1.17 (0.91 to 1.52), 0.23 | 1.07 (0.78 to 1.47), 0.68 | Omitted* | 0.99 (0.58 to 1.68), 0.97 |
| NNNS hypotonicity | 1.05 (0.93 to 1.19), 0.40 | 1.21 (1 to 1.46), 0.05 | 0.92 (0.67 to 1.27), 0.62 | Omitted* | 1.08 (0.67 to 1.73), 0.75 |
| NNNS stress | 1.10 (0.98 to 1.22), 0.11 | 1.15 (0.96 to 1.38), 0.12 | 1.05 (0.84 to 1.32), 0.66 | 0.90 (0.37 to 2.16), 0.81 | 1.35 (0.91 to 1.99), 0.13 |
| HNNE total score | 1.19 (1.05 to 1.33),<0.01 | 1.29 (1.06 to 1.57), 0.01 | 1.16 (0.91 to 1.49), 0.23 | 0.68 (0.23 to 2.02), 0.49 | 1.61 (1.09 to 2.38), 0.02 |
| HNNE tone optimality | 1.10 (0.97 to 1.23), 0.14 | 1.14 (0.94 to 1.38), 0.17 | 1 (0.77 to 1.29), 0.97 | 1.38 (0.58 to 3.29), 0.46 | 1.55 (1.02 to 2.34), 0.04 |
| HNNE tone patterns | 1.13 (0.98 to 1.31), 0.10 | 1.09 (0.86 to 1.37), 0.48 | 1.22 (0.87 to 1.70), 0.25 | 0.54 (0.09 to 3.06) 0.48 | 1.50 (0.91 to 2.46), 0.11 |
| HNNE reflexes | 1.17 (1.03 to 1.33), 0.01 | 1.37 (1.09 to 1.71), 0.01 | 1.05 (0.80 to 1.39), 0.72 | 0.38 (0.05 to 2.76), 0.34 | 1.41 (0.94 to 2.12), 0.10 |
| HNNE spontaneous movement | 1.11 (0.98 to 1.25), 0.09 | 1.26 (1.04 to 1.52), 0.02 | 1.04 (0.81 to 1.35), 0.74 | 0.42 (0.10 to 1.88), 0.26 | 1.15 (0.77 to 1.72), 0.50 |
| HNNE abnormal signs | 1.14 (1.01 to 1.28), 0.03 | 1.12 (0.93 to 1.34), 0.24 | 1.23 (0.94 to 1.61), 0.13 | 1.09 (0.44 to 2.69), 0.86 | 1.34 (0.88 to 2.06), 0.18 |
| HNNE behaviour | 1.11 (0.90 to 1.36), 0.32 | 1.20 (0.89 to 1.63), 0.23 | 1.02 (0.66 to 1.58), 0.94 | Omitted* | 1.52 (0.84 to 2.74), 0.16 |
| Abnormal GMs | 1.12 (0.99 to 1.26) 0.07 | 1.21 (1.00 to 1.46) 0.05 | 1.15 (0.91 to 1.45) 0.24 | 0.92 (0.41 to 2.05) 0.84 | 1.04 (0.71 to 1.53) 0.83 |
*Result omitted as too few numbers with suboptimal neurobehaviour and deep nuclear grey matter abnormality to analyse.
GMs, general movements; HNNE, Hammersmith Neonatal Neurological Examination; NNNS, Neonatal Intensive Care Unit Network Neurobehavioral Scale; WM, white matter.