Table 1.
Comparison of CA prevalence per 10 000 live births comparing BiB and BINOCAR data
| All live births in the BiB cohort (n=13 857) |
BINOCAR | |||||||
| Total* | Total excluding chromosomal and metabolic anomalies* | Total | Live births only (259 714) | Live births and stillbirths (260 927) | Total excluding chromosomal anomalies | |||
| ≤1 year old | Age 0–<5 years | ≤1 year old | Age 0–<5 years | |||||
| Any CA | 432.9 | 620.6 | 376.0 | 571.6 | 226.5 | 168.2 | 171.5 | 183.6 |
| Nervous system | 93.8 | 215.1 | 73.6 | 192.7 | 26.4 | 10.2 | 10.9 | 23.6 |
| Heart | 91.7 | 122.7 | 90.9 | 116.2 | 60.2 | 50.7 | 51.8 | 51.4 |
| Respiratory | 11.5 | 16.6 | 10.1 | 14.4 | 9.8 | 6.3 | 6.6 | 8.9 |
| Orofacial clefts | 25.3 |
27.4 | 25.3 | 25.9 | 14.3 | 12.6 | 12.9 | 13.2 |
| Digestive system | 39.7 | 48.4 | 35.4 | 37.5 | 18.1 | 15.3 | 15.7 | 16.2 |
| Abdominal wall defects | 2.2 | 2.9 | 2.2 | 2.9 | 9.1 | 5.3 | 5.4 | 7.3 |
| Urinary | 49.1 | 64.2 | 44.0 | 49.8 | 27.8 | 22.1 | 22.5 | 26.7 |
| Genital | 37.5 | 51.2 | 37.5 | 44.7 | 17.9 | 16.9 | 17.1 | 17.4 |
| Limb | 44.7 | 57.7 | 44.0 | 53.4 | 34.9 | 28.9 | 29.6 | 32.2 |
| Other/syndromes | 6.5 | 4.7 | 4.8 | 6.06 | ||||
| Skeletal dysplasia | 5.8 | 18.0 | 5.1 | 12.3 | 1.5 | 1.0 | 1.0 | 1.5 |
| Genetic syndromes and microdeletions | 13.0 | 17.3 | 11.5 | 14.4 | 4.9 | 4.0 | 4.0 | 4.6 |
| Sequences | 7.9 | 10.8 | 7.9 | 10.1 | 2.3 | 1.3 | 1.4 | – |
| Chromosomal | 25.3 | 32.5 | 0.00 | 0.00 | 43.0 | 14.9 | 16.6 | – |
BiB, Born in Bradford; BINOCAR, British Isles National Organisation of CA Registers; CA, congenital anomaly.