Table 2.

SNPs associated with NSCLC risk in both the discovery and validation populations

				Discovery		Validation		Meta-analysis
Position	Gene	SNP	Model	OR (95% CI)a	P-value	OR (95% CI)b	P-value	OR (95% CI)	P-value	P-het
chr7:55049691	EGFR	rs884904	Add	0.83 (0.69–1.00)	0.046	0.90 (0.82–0.99)	0.027	0.89 (0.82–0.96)	4.36 × 10–3	0.433
chr7:55067570	EGFR	rs7809332	Add	0.86 (0.76–0.97)	0.014	0.91 (0.86–0.97)	5.76 × 10–3	0.90 (0.85–0.95)	3.54 × 10–4	0.397
chr6:47069911	ADGRF1	rs1226500	Add	1.17 (1.05–1.31)	5.53 × 10–3	1.06 (1.00–1.12)	0.049	1.08 (1.03–1.13)	2.77 × 10–3	0.108
chr6:47105069	ADGRF1	rs6941183	Dom	1.23 (1.06–1.42)	5.37 × 10–3	1.09 (1.01–1.18)	0.021	1.12 (1.05–1.20)	8.97 × 10–4	0.155
chr19:15164225	NOTCH3	rs3815188	Dom	0.85 (0.72–0.99)	0.042	0.91 (0.84–1.00)	0.045	0.90 (0.83–0.97)	6.62 × 10–3	0.423
chr19:15160648	NOTCH3	rs2238643	Add	0.88 (0.78–0.99)	0.027	0.94 (0.89–1.00)	0.048	0.93 (0.88–0.98)	6.80 × 10–3	0.318
chr15:65215388	SMAD3	rs2118610	Dom	1.26 (1.08–1.47)	3.98 × 10–3	1.12 (1.04–1.21)	4.23 × 10–3	1.15 (1.07–1.23)	1.02 × 10–4	0.190

Add, additive model; Dom, dominant model; P-het, P for heterogeneity test.

^aAdjusted for age, sex and smoking status.

^bAdjusted for age and sex.